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KMID : 0603520000050020081
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Journal of Korean Association of Cancer Prevention
2000 Volume.5 No. 2 p.81 ~ p.86
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Anticarciogenic Effect of Kimchi Extract on 2-AAF-induced Rat Hepatocarcinogenesis System
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Park Kun-Young
Kim Hyoung-Chin
Jung Keun-Ok
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Abstract
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Anticarcinogenic effect of the methanol extract from kimchi was determined in a new medium-term carcinogenicity bioassay using D-galactosamine (DGA) as a nonsurgical method to induce liver cell regeneration in place of partial hepatectomy (PH). Male F344 rats were initially given a single i.p. injection of diethylnitrosamine (DEN, 200 ㎎/㎏) and received 2 i.p. injections of D-galactosamine (DGA, 300 ㎎/㎏) at the end of week 2 and 5. They were treated with oral administration of 2-acetylaminofluorene (2-AAF, 7 ㎎/㎏) and kimchi extract (920 ㎎/㎏) for week 3∼8 (5 days/week). Anticarcinogenic effect was assessed by comparing the numbers and areas per square centimeter of glutathione S-transferase placental form-positive (GST-P+) foci in the livers of kimchi extract-treated animals with those of the control animals given 2-AFF alone. No difference was noted in body weights between control and kimchi treated
group. Liver weights and liver/body weight ratios were not changed in rats treated with kimchi sample. The mean numbers of GST-P+ foci in livers of control and kimchi-treated group were 13.8 and 8.8/㎝2, respectively. The areas of GST-P+
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KEYWORD
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Kimchi, GST-P, foci, 2-AAF, Hepatocarcinogenesis
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